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In some trials, iron supplements were also given to children, which is also a treatment for anaemia, and we took this into consideration when analysing the data.
Similar to the overall analysis, we found significant reductions in the risk of anaemia (relative risk 0.56, 0.48 to 0.65; I=75%; 17 trials), iron deficiency (0.59, 0.44 to 0.79; I=79%; eight trials), and iron deficiency anaemia (0.37, 0.23 to 0.60; I=47%; five trials) (supplementary figures 21-23).
Accordingly, increasing iron intake by young children has been the focus of most research and public health programming, and, in randomized trials, iron supplements or iron-fortified foods reduce anemia in young children by about 37% 62% [ 25], leaving a substantial portion of child anemia unaddressed.
In six trials iron and folic acid were routinely administered to all pregnant women (Fleming 1986 NGA; Mbaye 2006 GMB; Nahlen 1989 NGA; Njagi 2003i KEN; Njagi 2003ii KEN; Parise 1998i KEN; Parise 1998ii KEN; Villegas 2007 THA), in one trial only iron was administered (Shulman 1999 KEN), and in one trial both iron and folic acid were given to anaemic women (Nosten 1994 THA).
Similar(56)
Data monitoring committee has not been established since the intervention within the trial (iron 1 mg/kg per day) does not differ from standard of care in infants from risk groups.
In addition, in 14 trials of iron against placebo, the use of iron was associated with a birth weight increase of one and a half ounces, on average.
Thus, randomized controlled trials of iron supplements are needed to evaluate the exact effect of iron supplements on Hb changes during pregnancy and on birth outcomes.
Four trials gave iron as part of the intervention.
There are similarities between our results and the results of other earlier controlled trials of iron supplementation in pregnancy.
A meta-analysis of 49 trials of iron and folic acid similarly found no effect on birth weight or prevalence of low birth weight (24).
A meta-analysis of four trials of iron supplementation during pregnancy, with and without folic acid, [ 60] showed a reduction in anemia but no significant effect on preterm birth (RR 0.76; 95% CI 0.47-1.24) or low birth weight (RR 0.59; 95% CI 0.23-1.49).
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