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Five trials investigated an exercise intervention group compared to a control group [50-54] [50-54]
Four of the six included trials investigated only female participants, and one trial included only male participants.
Several trials investigated the incidence of specific injuries, including hamstring [50,52], ankle [55,56], Achilles and/or patellar tendon [51] or groin injuries [53].
Two included trials investigated the unwanted tooth movements (canine tipping and rotation, molar anchorage loss, transverse changes) associated with MISAO [39, 40].
Five randomized trials investigated the effects of low-to-moderate doses of corticosteroids when initiated within the 24 hours of onset of severe sepsis [25, 42 46].
Most trials investigated drugs.
Only three trials investigated exercise referral.
All trials investigated complex interventions with various components (web table).
Two trials investigated gabapentin in a dose-response regimen.
In total, 12 trials investigated small molecule tyrosine kinase inhibitors.
The majority of previous controlled trials investigated aerobic exercise.
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