Sentence examples for trials in high from inspiring English sources

We conducted a retrospective study, pooling data from two clinical trials in high risk soft tissue sarcoma (STS) patients, with the objective of comparing two different age groups: 15 29 years (adolescents and young adults (AYA) population) and ⩾30 years.

Together, our studies identify IGF1R as a high value target for clinical trials in high risk medulloblastoma.

Two large prophylactic trials in high incidence, clade C epidemic regions in southern Africa are imminent; passive administration of the monoclonal antibody VRC01, and active immunization with a clade C modified RV144-like vaccines.

Absolute quantification of MRI brain volumes may overcome this limitation for improving neurodevelopmental outcome prediction [11], [12], [13] and qualify as a surrogate endpoint for clinical trials in high risk newborns [13], [14].

This study corroborates and extends the value of non-human primate TB models by further defining and correlating pathologic, radiologic, bacteriologic, clinical and hematologic read-outs, which improves vaccine selection prior to expensive and time-consuming clinical Phase IIb/III efficacy trials in high transmission areas.

Proportional use of patches closer to the nest or to the wall did not differ from 1, one-sample t-test with n = all 24 trials, t = 1.1, p = 0.281; and with n = 12 trials in high risk treatment, t = 0.97, p = 0.354).

Squamous dysplasia, the accepted histological precursor for esophageal squamous cell carcinoma, represents a potentially modifiable intermediate end point for chemoprevention trials in high-risk populations.

This effort focuses on increasing the availability of oximetry in perioperative settings, though randomized controlled trials in high-income countries have yet to demonstrate that oximetry reduces morbidity or mortality in this setting [6, 7].

However, encouraging preliminary single-center pre-post European pilot studies [92] have shown reductions in delirium incidence and duration in patients considered at high risk after prophylactic low doses of haloperidol, and support moving forward with multicenter prophylaxis trials in high-risk ICU populations.

In this context, our results should help to optimise the design of further clinical trials in high-risk breast cancer.

We recognize that actual clinical relevance must be demonstrated definitively via future randomized controlled trials in high-risk older populations.