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Although a few trials have explored whether bisphosphonates (BPs) prevented recurrent fragility fractures (FFs), little is known about the secondary preventative effects of BPs.
More recent trials have explored new techniques, including thoracoscopic insufflation of talc and small-bore catheters.
Furthermore, at least two randomized, controlled trials have explored lactate clearance as a potential resuscitation goal for septic shock patients with encouraging results [5, 6].
Several trials have explored whether or not NOS inhibition is effective in allergic bronchitis.
No intervention trials have explored the effect of dietary fibre intake on CVD or all-cause mortality risk.
Two other trials have explored a nab-paclitaxel regimen qw 3/4 in combination with bevacizumab for treatment of MBC.
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None of the clinical trials has explored the molecular mechanism of the EPO-mediated adverse events.
While prehospital resuscitation has been rigorously tested in other time-sensitive syndromes, such as trauma and cardiac arrest [ 11– 13], no trial has explored the benefit or harm of fluid resuscitation in prehospital sepsis.
Although OPTIMA is the motivating trial, we have explored a wider range of scenarios so that the work is informative for other trials also.
This is the first trial to have explored the use of medium-term (6-months) antibiotic prophylaxis in patients who have had cellulitis of the leg.
Phase I trials with FTIs have explored different schedules for prolonged administration, and dose-limiting toxicities included myelosuppression, gastrointestinal toxicity and neuropathy.
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