Sentence examples for trials have documented from inspiring English sources
Numerous trials have documented the contribution of proinflammatory cytokines in the pathophysiology of pain associated with peripheral and central nociception.
Many trials have documented increased clearance with oral AC in both human and animal models after intravenous (IV) phenobarbital, phenytoin, digoxin, acetaminophen and theophylline (Table 1).
Numerous trials have documented moderate efficacy with benzodiazepine receptor agonists [ 12, 13].
Moreover, clinical trials have documented the benefits of probiotics in some critically ill patients [ 12- 18].
Clinical trials have documented exciting success in the treatment of patients with rheumatoid arthritis, autoimmune cytopenias, and allergic rhinitis.
26 In the past two decades, numerous trials have documented beneficial effects of glutamine supplementation in critically ill patients.
As shown in table 1, all but 3 of the 28 trials had documented plans for PPI in their grant application or protocol or both.
Evaluative analyses of data from the same trial have documented improvements according to six HRQL measures and the six-minute-walk test [ 9], and have shown important differences among results from four major generic HRQL measures [ 10].
It is interesting to note that the above study (Rocha-Lima et al, 2004) and the present trial have documented a similar efficacy achieved with the irinotecan gemcitabine combination; however, gemcitabine monotherapy resulted in a relatively low response rate (Rocha-Lima et al, 2004) which may account for the observed statistical difference.
In addition, all patients in the REDOXS trial had documented multi-system organ failure at enrollment, which is a common exclusion criteria in the trials reported in this analysis using parenteral GLN as a supplement to nutrition support.
To our knowledge, only 1 randomized clinical trial has documented improved interim treatment outcomes (reduced time to sputum culture conversion and higher proportion with sputum culture negative 6 months after treatment started) among patients receiving high-dose isoniazid (16 18 mg/kg) as an adjuvant to second-line drugs in documented MDR TB (15 ).
