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The first oncolytic Ad was approved as a drug in China in 2005, although clinical efficacy observed in human trials has failed to reach the high expectations that were based on studies in animal models.
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However, numerous clinical trials have failed to show evidence that the implants cause disease in humans.
Although several initially promising agents have been developed to reverse or at least slow the decline of cognitive function, successive experimental trials have failed.
Despite knowing that three trials had failed to prove its effectiveness on children, Glaxo published a report entitled "Positioning Paxil in the adolescent depression market – getting a headstart".
In fact, all of the nearly 90 preventive HIV vaccines that have made it to human trials have failed despite working in other primates.
Contrary to the arguments of Dr. Kramer, many sound clinical trials have failed to find antidepressants effective at all in mild to moderate depression.
So far, sepsis trials have failed to rule in or out survival benefit from corticosteroids.
The more recent and better designed trials have failed to demonstrate the benefits of operative treatment.
To date, clinical trials have failed to show any improvement in outcome beyond the placebo effect.
Nevertheless, small randomized controlled trials have failed to demonstrate a survival advantage.
Several randomized trials have failed to identify major differences in survival between any of these doublets.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com