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OPB-31121, an anticancer compound currently in clinical trials, has been reported to affect STAT3 signaling, although its mechanism of action has not been unequivocally demonstrated.
Despite the concerns of time trend in subject profiles, the use of Bayesian response adaptive randomization (BRAR) in large multicenter phase 3 confirmative trials has been reported in recent years, motivated by the potential benefits in subject ethics and/or trial efficiency.
To date, only a limited number of clinical trials has been reported using both a demethylating and an HDAC inhibitor for treatment of hematological [9] and solid tumors [10].
Single-agent activity of cediranib in phase II trials has been reported [ 206, 207].
The most recent of these trials has been reported on in Critical Care (Paper report: ).
Therapeutic response with obatoclax in clinical trials has been reported to be low and its development has been halted [ 68].
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However, few trials have been reported in past literature.
No randomized controlled trials have been reported evaluating the efficacy of WBI.
The results obtained through field trials have been reported and found to be quite encouraging.
Results from their many successfully completed trials have been reported as subset analyses, pooled analyses, and retrospective studies.
Mass media interventions for reduction of youth cigarette smoking have been recommended based on a broad array of evidence, although few randomized community trials have been reported.
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