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New capacity in high disease burden countries to manage complex, large-scale efficacy trials has been established, and historical clinical trials offer crucial insights into the biology of TB.
To date, no quantitative relationship using summary-level efficacy and safety data across trials has been established between different paclitaxel dose and regimen vs. efficacy or safety end points.
While the value of the inclusion of unpublished literature in meta-analysis of randomised control trials has been established [ 85] it has not been established for a narrative review such as this whether the absence of unpublished empirical studies biases or detracts from the overall conclusions.
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Silvicultural trials have been established to evaluate stand-level responses to treatments and operational aspects of the approach.
Successful trials have been established in animal disease models of bladder (Yoo et al., 1998), skin (Schechner et al. 2003), heart (Ott et al., 2008; Wainwright et al., 2010), and lung (Cortiella et al., 2010; Petersen et al., 2010).
While randomized controlled trials have been established as the gold standard for efficacy evaluation, comprehensive safety assessment requires a collection of different methods.
To further understand the interactions between pruning stress and disease development, a separate trial has been established in which 180 trees were pruned to induce a stress response.
Sample size for this equivalence trial has been established using power analysis incorporating data from journal article reports of similar ACDF studies.
The STEP-UP trial has been established to investigate a bilateral sequential segmental approach for vapour ablation and has been designed to conserve a balance between the treatment's safety and efficacy profiles.
The NIMH Stanley Foundation Bipolar Treatment Outcome Network, a multisite clinical trials network, has been established to address many of the neglected areas of research in bipolar illness.
A Data Monitoring Committee (DMC), independent of the trial investigators, has been established.
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