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The evaluation of the bioavailability of bioactive compounds from cruciferous foods is one challenge in the design of clinical trials for studying their functionality.
A more problematic aspect of the use of randomised trials for studying late effects is that, as they are not pre-specified trial end-points, they are often not reported in papers presenting trial results unless the findings are in some way remarkable.
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This study is a multicenter randomized two-group trial for studying the added value of therapists phone support outside office hours.
In this protocol we have presented the first controlled trial for studying aversive tension in patients with AN in an ambulatory monitoring setting.
6 We found 19 articles proposing or employing novel clinical trial methods for studying therapeutic interventions in rare diseases.
17 They and Gupta and colleagues have also proposed frameworks to aid selection of randomized clinical trial methods for studying health outcomes in rare diseases.
We contacted the authors of trials for study clarifications, where required.
We systematic searched PubMed, EmBase, MEDLINE, and the Cochrane Central Registered Controlled Trials for studies conducted prior to May 2013, using the following keywords: trastuzumab, pertuzumab, lapatinib, and breast cancer.
13 A systematic search of Medline in PubMed, Embase, and the Cochrane Library database (the Cochrane central register of controlled trials) for studies reporting an infection as an adverse event or cause of death related to statin use was done from inception to 10 March 2011.
The permuted locus trial was originally intended for studying the influence of water wells on trachoma.
Secondly, these data were to propose the choice of clinically relevant effects for future trials studying antiemetic interventions for the treatment of PONV.
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