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The gemcitabine-based chemoradiation platform is a reasonable foundation on which to build future phase II multimodality trials for stage I/II pancreatic cancer incorporating emerging systemic therapies.
It will be interesting to complement the genetic alteration and differential expression profiles of these molecules as biomarkers in future clinical trials for stage II CRC patients.
Fexinidazole is currently in clinical trials for stage 2 HAT (see section 6.2 .. Fexinidazole is rapidly oxidized in vivo in mice, dogs, and humans to the sulfoxide and sulfone metabolite.
New clinical trials for Stage III gastric cancer are either currently ongoing or under preparation based on the fact that hazard ratio for the treatment group incrementally increased as the clinical stage advanced from II to IIIB in a randomized trial comparing adjuvant S-1 monotherapy versus surgery alone [ 25].
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To date, it is undergoing phase I trial for stage III or IV PC patients.
In a phase III trial for stage IV melanoma, ipilimumab administered with or without a gp100 peptide vaccine was compared with gp100 alone.
BrUOG BR-211B (NCT00617942) was a pre-surgical trial for stage II-III HER2+ breast cancer patients led by the Brown University Oncology Group (BrUOG) and the Yale Cancer Center.
Hitler used his trial for staging the Munich putsch to propagate National Socialism and went to jail a martyr for the Nazi movement.
SIGN guidelines currently recommend adjuvant chemotherapy for patients with stage C colorectal cancer, entry into randomised trials for Dukes' stage B, and palliative chemotherapy for all patients with advanced or metastatic cancer.
StaphVAX is currently in phase III trials for end-stage renal disease, but phase II trials are under way in postoperative and long hospital stay patients.
Given the poor prognosis of stage II patients compared with stage I patients, many investigators have advocated for the inclusions of stage II patients into clinical trials for advanced (stages III IV) cancers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com