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The design of clinical trials for prevention or treatment of acute or chronic graft-versus-host disease poses many challenges.
We chose to study the effects of combined administration of vitamins C and E as they act synergistically in vitro [22] and are used in most clinical trials for prevention of preeclampsia [2] [7].
COX-2 inhibitors have demonstrated impressive efficacy in clinical trials for prevention and adjuvant therapy [ 16, 17].
This approach of reporting potentially fatal gestational hypertensive related maternal morbidities have also been adopted in antioxidant trials for prevention of pre-eclampsia [ 51].
The presence of prediabetes or diabetes may be a motivation to participate in long-term intervention trials for prevention of diabetes or optimization of glycemic control [ 6- 10].
A similar debate applies to vitamin D supplementation trials for prevention of fractures, cardiovascular disease, and other health outcomes (1, 2, 5, 16, 29– 33).
Similar(51)
The two latter groups were enrolled in a randomized multicenter trial for prevention of preeclampsia.
The largest LMWH trial for prevention of VTE in patients with active cancer had only 672 randomized patients [ 33].
This increased incidence has not been confirmed in HORIZON-RFT, the Paget trial, 54 nor the trial for prevention of PMO.
This was a multi-site parallel randomised controlled trial for prevention of diabetic nephropathy progression among 112 Japanese type 2 diabetic patients with overt nephropathy.
This is a particularly important issue, since abatacept is a potential candidate to be tested in a trial for prevention of T1D in individuals determined to be at high risk for the disease.
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CEO of Professional Science Editing for Scientists @ prosciediting.com