Improved knowledge from large prospective population-based studies, with diary-confirmed diagnosis as well as clinical trials for improved management is indicated.
This research describes the utility of screening for severity of symptoms prior to entry into clinical trials for symptom management in cancer.
The design, analysis and interpretation of randomised controlled trials for the management of early breast cancer are to some extent predicated on the prevailing conceptual model of the disease based on its biology and cellular kinetics.
Tolvaptan, an oral V2R antagonist, has been assessed in several trials for the management of acute and chronic heart failure.
Systematic reviews of clinical trials for the management of tendinopathies commonly report on the inconsistency of outcome measures which limits data synthesis and meta-analysis.
Thus, it is justified to propose further evaluation of these drug candidates in clinical trials for the management of intestinal fibrosis.
Results from small clinical trials suggest that nitazoxanide and teicoplanin may be alternative options to standard therapies, whereas rifaximin has demonstrated success in uncontrolled trials for the management of multiple recurrences.
The Diabetes Prevention Program [ 7] and other lifestyle interventions for adults at high risk for T2D [ 8, 9] have provided a model for clinicians and researchers upon which to base the design, delivery, and evaluation of clinical trials for T2D management.
We note in this respect that treatment with humanized antibodies against SOST (a secreted LRP5 antagonist) is currently in phase III trials for osteoporosis management (McClung and Grauer, 2014).
Topiramate has been reported to have positive effects on pain relief in diabetic peripheral neuropathy, 7 an effect which has been shown to be durable 40 in clinical trials for the management of diabetic peripheral neuropathy pain syndromes.
