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Ten healthy males completed two, 8 h trials (exercise and control) in a randomised-crossover design.
Evidence indicating a benefit of fluid intake on intermittent (10 trials), resistance (9 trials), sport-specific (6 trials) and balance (2 trials) exercise and on cognitive performance (15 trials) was less apparent and requires further elucidation.
In n = 11 trials, exercise was performed in a warm or hot environment (30 40 °C), by acclimated (n = 2) [63, 77] and unacclimated (n = 5) [29, 36, 47, 62, 76] subjects, where environmental adaptation was specified.
In previously reported trials, exercise has been provided to all participants [ 8], rather than being targeted to those most likely to benefit.
In randomized control trials, exercise has been shown to be nearly as effective as medication.
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Univariate meta-regression analysis found no significant effect of the year of recruitment to the trial, exercise mode, format of exercise training or prescribed intervention duration, session frequency or time on PCI outcomes (Additional file 1: Table S9e).
However, the Amici Curiae did point out that the Trial Chamber would have to consider the extreme scale of the single trial exercise and whether the Chamber was able adequately to deal with it (Prosecutor v. Milošević 5 December 2001, p. 6).
Univariate meta-regression analysis found no significant effect of the year of recruitment to the trial, exercise mode and exercise provider; how the exercise was delivered; or the prescribed intervention duration, session frequency, time or intensity on cardiovascular mortality outcomes (Additional file 1: Table S9a).
This was assessed by the referring clinician and confirmed by the trial exercise therapist.
Although participants in the usual care arm were not offered the trial exercise programmes, they were free to participate in any other exercise opportunities.
A search strategy was designed using keywords, mesh terms, and free text words such as aged, frail elderly, randomized controlled trial, exercise, and gait speed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com