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Three authors (EPN, MK, and VS) independently reassessed the trials' eligibility and ranked their risk of bias.
In average, about half of all patient characteristics mentioned in the trials' eligibility criteria could be documented in structured data elements within their EHR.
The characteristics of the biodegradable polymer and durable polymer stents, including the stent material, polymer coating, and drug eluted, along with the polymer degradation kinetics, are summarized in supplementary table E. Five authors (SB, BT, SK, MF, and NA) independently assessed trials' eligibility and risk of bias and extracted data.
Extension for pragmatic trials: Eligibility criteria should be explicitly framed to show the degree to which they include typical participants and, where applicable, typical providers (eg, nurses), institutions (eg, hospitals), communities (or localities eg, towns) and settings of care (eg, different healthcare financing systems).
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Since determination of trial eligibility will be automated using routinely collected cohort measures, all patients who are eligible for an active SPIN trial at a given point in time will automatically be administered the trial-specific measures.
We found that criteria for clinical trial eligibility are frequently under-reported in medical communications.
Incorporating standardized comorbidity measurement, relaxing clinical trial eligibility criteria, and utilizing novel trial designs are critical to developing a larger and more generalizable evidence base to guide the management of these patients.
We aimed to determine whether a prospective TB is an effective strategy for trial recruitment and to identify steps within the TB process that facilitate discussion of trial eligibility and optimize accrual.
The classic single-arm oncology phase II trial designs for evaluating an experimental regimen/agent are limited by multiple sources of bias arising from the inability to separate trial effects (such as patient selection, trial eligibility, imaging techniques and assessment schedule, and treatment locations) from treatment effect on clinical outcomes.
Two authors independently assessed trial eligibility and quality.
One reviewer (IS) assessed trial eligibility, under the supervision of the senior authors (PRW and RLS).
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