60 For pragmatic trials, efforts that may reduce this natural variation in the intervention and its delivery should be described.
Hence, maintenance of A1C at or below near-normal entry levels in ORIGIN contrasts with the other trials' efforts to restore previously inadequate glycemic control.
Because it will not be possible to test many agents in large randomized clinical trials, efforts are underway to develop useful tissue-based surrogate end-point biomarkers that can be used to select only the most promising agents (and doses) for large-scale trials.
Since it will not be possible to test many agents in large randomized clinical trials, efforts are underway to develop useful tissue-based surrogate end-point biomarkers that can be used to select only the most promising agents (and doses) for large-scale trials.
In major trials, efforts should be taken to limit and quantify treatment contamination with close follow-up of study participants, surveys to assess and optimise adherence, and use of intermediate measures of adherence and effectiveness (such as following change in low density lipoprotein in cholesterol trials that are powered for survival).
As such, a comprehensive and unbiased survey to identify the most prevalent molecular targets in gastric cancer could facilitate many aspects of gastric cancer translational research, for example, in focusing clinical trials efforts on those therapies that might benefit the greatest numbers of gastric cancer patients.
You would be wise to burn all letters, including this one, and forget you mentioned it.KENNETH DORANMadison, WisconsinSIR—I have subscribed to your newspaper as a trial effort, anticipating a high-brow experience that would not only assist me in my profession but add to my high-school son's education.
The disheartening debacle of the one-day Allied trial effort in August 1942 to breach the Atlantic Wall with a raid against the modest German garrison at Dieppe, France, provided crucial lessons that led directly to the world-important success on D-Day two years later.
Prior to initiating this trial, effort to characterize the instrument's amplitude and phase responses, and standardize them between replicated instruments was required [ 32, 33].
Still, the technology is getting sudden attention in response to several trial efforts around the country and in other nations.
