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In the 12-week, active-controlled trials, efficacy was also assessed at day 2 (Table 1).
Uremia represents a state where hyperhomocysteinemia is resistant to folate therapy, thus undermining intervention trials' efficacy.
Clinical trials (efficacy) or meta-analyses of clinical trials are the preferred sources of outcome data in six agencies [ 7, 19, 21, 25, 30, 35].
In most clinical trials, efficacy did not differ substantially between tocilizumab monotherapy and combination therapy at 6 months, whereas long-term comparative data are lacking.
Based on clinical trials, efficacy of exenatide appears more optimal in those who have not had long diabetes duration and those who have adequate endogenous insulin.
Basic research needs to be undertaken, followed by clinical trials, efficacy and safety studies, before new clinical practices are brought into routine treatment.
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Pharmacokinetics and/or pharmacodynamics were studied in 147 (45%) trials, efficacy-only in 13 (4%) and safety-only in 38 (12%).
The present research compares randomly selected 20-year-old men who took part in a scientific trial (efficacy) with those who voluntarily sought an intervention (effectiveness).
Normal distribution was used for the original trial efficacy data and rates of events combined with the observed cost estimates.
It is important to recognise that there is likely to be a gap between trial efficacy and programmatic effectiveness for multi-day regimens.
In a bid to reflect effectiveness rather than trial efficacy the costs of research staff used as adherence monitors were excluded from this analysis.
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