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As a consequence, clinical phase I trials document a wide range of side effects.
The MAPEC study plus other earlier conducted less refined trials document the asleep BP mean is the most significant prognostic marker of CVD morbidity and mortality.
It's not uncommon in medicine for innovative therapies to be used in patients before well-designed trials document their utility.
Cohort studies following participants enrolled in industry sponsored trials document low rates of discontinuation due to adverse effects, 12%% over 12 months on OROS methylphenidate, 15- 21 % over 24 months on mixed amphetamine salts, 11%% discontinued atomoxetine over more than 2 years [ 1].
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Multiple, prospective trials have been performed comparing open and endovascular TAA repair with three company sponsored trials documenting clinical equipoise.
Widespread application of transjugular intrahepatic portasystemic shunt (TIPS) continues despite the lack of trials documenting efficacy superior to surgical shunting.
Second, a series of randomized controlled trials documents the beneficial effects of cognitive behavioral therapy (CBT) in children exposed to sexual abuse.
These trials documented a significant reduction in adenoma formation in patients at high risk for colorectal cancer, with reductions in advanced disease occurrence from 28 66% over 3 years.
Despite extensive clinical trials documenting efficacious clinical response to therapy, there is a paucity of data investigating the molecular mechanisms by which etanercept modulates the improvement of psoriasis.
The trials documented in the report generally aimed to streamline access to existing government programs and improve efficiency.
The two pivotal trials documented a strong influence of the applied lamp sources on PDT efficacy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com