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Also, since five trials differentiated between MACE and cardiac-cause hospital readmissions, we performed an analysis according to the latter outcome, which occurs more frequently.
There were six blocks of trials, differentiated by the memory set of possible target items.
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In addition, this trial differentiated itself from the initial Attard trial [ 39] by enrolling patients who had received prior treatment with ketoconazole.
But for the companies, the competition could mean smaller markets for each drug and costlier clinical trials to differentiate a product from its competitors.
Because of these complexities, we must conduct clinical trials that differentiate between the specific and non-specific effects of a treatment.
The Finnish law makes an arbitrary distinction between medical research and other health research, and the European Union's directive for good clinical trials further differentiates drug trials.
The other issue is the evaluation of assay sensitivity, which refers to the ability of a trial to differentiate an effective treatment from a less effective or ineffective treatment [ 5].
Since this could increase right ventricular (RV) afterload, we investigated the effect of this method on RV outflow impedance during inspiration and expiration using transoesophageal echo-Doppler in a trial to differentiate the RV consequence of increasing lung volume from those secondary to increasing airway pressure during mechanical ventilation.
Previous studies exploring the completeness of intervention descriptions in clinical trials have not differentiated between different trial designs and have not explicitly assessed the completeness of reporting of enabling or support activities used to assist professionals in implementing the interventions being tested.
85 Despite the large number of patients included in the trials, power to differentiate across interventions is potentially an issue.
Without complete and transparent reporting of how a trial was designed and conducted, it is difficult for readers to assess its conduct and validity or to differentiate trials with unbiased results from those with questionable results.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com