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Drug side effects often arise from case reports or randomized trials designed for another purpose.
Anastrozole was evaluated in two separate trials designed for combined analysis.
Physician education and more clinical trials designed for older women are needed.
How strong and reliable are the clinical trials designed for their use alone or in combination with conventional chemotherapy?
Data from spacing trials that were measured annually over a 25-year period (Amateis and Burkhart 2012) and from silvicultural trials designed for estimating response to control of competing vegetation and fertilizer applications extend and enhance the basic modeling framework.
This paper examines the factors pertinent to the small number of clinical trials designed for metastatic colorectal cancer in this group of persons.
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Elements of ideal trials designs for successful antiepileptogenic intervention are suggested.
MINDACT, for example, is a trial designed for validating a genomic signature for breast cancer.
Thus, the aim of this paper is to describe the randomized controlled trial designed for evaluating effectiveness of EoP, and to present results from validations of outcome measures.
Martin Posch was supported by the EU FP7 HEALTH.2013.4.2-3 project Advances in Small Trials dEsign for Regulatory Innovation and eXcellence (Asterix): Grant 603160.
Clinical trials specifically designed for these objectives are warranted.
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