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The trials demonstrated significant reductions of up to 0.5 log10 in plasma viral load and up to 0.3 log10 in genital HIV load among HIV-HSV-2 coinfected persons during HSV-2 suppression [46], [47], [48], [49], [50], [51].
Subgroup analysis of these trials demonstrated significant mortality and morbidity benefits in diabetic patients.
All of these trials demonstrated significant reductions in late lumen loss at 6 months and lower rates of target lesion revascularization at 1 year for DCB versus PTA.
One of these trials demonstrated significant effects of scalp acupuncture on symptom relief [ 12, 15], but the other trial failed to significantly reduce OAE [ 12, 15].
A contemporary meta-analysis of randomized controlled trials demonstrated significant short and long term improvements associated with inpatient geriatric rehabilitation related to functional status, admission to nursing homes and mortality [ 1].
For the past decade or more, multiple clinical trials demonstrated significant effects of pharmacologic (primarily statin) therapy on CVD outcomes in subjects with CHD and for primary CVD prevention (245).
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There was statistical heterogeneity in the surgical subgroup, with some trials demonstrating significant benefit and others demonstrating significant harm, but no surgical subgroup consistently benefited from IIT.
Two large trials in Kenya have shown that SMS messages can improve antiretroviral adherence among patients with HIV/AIDS, with one of those trials demonstrating significant improvements in viral suppression [ 17, 18].
A HER2 targeted monoclonal antibody, Trastuzumab, has been evaluated in four large randomized clinical trials demonstrating significant benefits in disease free survival (DFS) with the addition of one year of Trastuzumab to adjuvant chemotherapy[ 5, 6].
Subsequently, in the early 2000s, with randomized control trials demonstrating significant improvements in LC and survival with concurrent chemotherapy 13, 14, our institution established chemoRT as the standard first-line therapy for patients with advanced BOT SCC 18.
42 The CONQUER trial demonstrated significant improvements in relation to glycemic profiles.
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