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In aggregate, the fish oil trials demonstrated a reduction in total mortality and sudden death without a clinically significant reduction in nonfatal myocardial infarction.
Future research should also consider whether participants have a history of injury, as both of the included trials demonstrated a reduction of hamstring injury recurrence with eccentric training [50,52].
A meta-analysis of five randomized trials demonstrated a strong reduction in the SOFA score at 1 week after randomization (weighted mean difference, -1.47 [-2.01, -0.92], P < 0.00001, with no heterogeneity in the results: I2 = 2%) [36].
In addition, the first clinical trials demonstrated a beneficial effect in breast and colon cancer.
Moreover, the times to achieve peak acceleration, peak velocity and peak deceleration for D0 and D2000 group no-mask and mask trials demonstrated a scaling effect with target ID.
However, clinical trials demonstrated a worsening in psychotic symptoms [ 160].
All of these trials demonstrated a slight non-significant trend towards a survival advantage for CAP.
The 3 high dose trials demonstrated a statistically significant 26% relative risk reduction in hip fractures.
None of these trials demonstrated a benefit for wider margins (Table 1).
None of the trials demonstrated a statistically significant reduction in the primary combined cardiovascular end points.
Two pivotal phase III randomized controlled trials demonstrated a survival benefit in patients with metastatic melanoma.
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