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The recognition index D1 was calculated by subtracting the time spent exploring the familiar item from the time spent exploring the novel item (i.e., time novel time familiar) and was summed across trials (cumulative D1).
We searched Medline, Embase, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Allied and Complementary Medicine Database (AMED) and five Korean databases up to February 2013.
We will search African Index Medicus, AFRO Library, the Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health, Dissertation Abstracts International, EMBASE, Education Resources Information Center, Western Pacific Region Index Medicus, Literatura Latinoamericana y del Caribe en Ciencias de la Salud, MEDLINE and PsycINFO for relevant studies.
The following databases were searched for relevant studies published without date limits up to the date of the search (September 2013): the Cochrane CENTRAL Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature, MEDLINE, PsycInfo, and the ISI Web of Knowledge/Science/Conference Proceedings Citation Index.
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The combined trial cumulative incidence for crude rate of ulcers by visit is shown in Figure 2. Results of the pooled analysis of the two studies are also shown in Table 2.
In all trials the cumulative dose of vitamin A was ≤50 000 IU, given as a single dose in five trials and as two doses in one trial.
The number of trials and cumulative sample size of hip fracture clinical trials were analyzed with respect to geographic region (city, country, and continent).
Trials with cumulative dose of ≥ 60 mg (or at least 6 weeks of therapy) demonstrated a significant effect (standardized mean difference, -0.59 units; 95% CI, -1.01 to -0.17); whereas, trials with cumulative dose < 60 mg (or less than 6 weeks of therapy) failed to demonstrate a salutary effect on this endpoint (standardized mean difference, 0.02; 95% CI, -0.59 to 0.62).
Electronic searches were conducted in the following databases from inception to February 2013: Ovid Medline, Cochrane Central Register of Controlled Trials, Embase, Cumulative Index to Nursing and Allied Health Literature CINAHLL) and the Allied and Complementary Medicine Database (AMED).
In PERI DOTS trials, the cumulative perimeter of the dots remained constant (p = 60 cm), thus, the radius and summed area across all dots increased with number (radius range: 1.19 cm – 0.32 cm; area range: 9.6 cm – 35.92 cm).
Although a wide variety of doses and schedules was used in these trials, with cumulative dose per cycle ranging from 8 to 14 mg/m, this did not have a clear impact on efficacy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com