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Clazosentan, magnesium, and simvastatin have been tested in large high-quality trials but failed to show a beneficial effect.
In addition, drugs such as NMDA receptor antagonists to halt neurochemical cascades such as excitotoxicity showed promise in animal trials but failed in clinical trials.
(72) Other Chk1/Chk2 inhibitors with improved specificities, including XL844 and AZD7762, also entered clinical trials but failed to achieve a good response.
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Unfortunately, each fresh effort increases the risk of getting the right result for the wrong reason, and winding up with a spurious vision of something that doesn't turn out to be scientifically robust, like a cancer drug that seems to work in trials but fails to work in the real world How on Earth are we going to do better?
After the Croatian intelligence archives were opened, the defense asked for a new trial, but failed to gain one.
One agency document concluded that Sanofi-Aventis knew of some of the problems in this trial but failed to alert the F.D.A. before the agency discovered the problems on its own.
Both sides in the convoluted legal battle over Mikhail B. Khodorkovsky's now-defunct Yukos Oil were claiming victory on Tuesday after the European Court of Human Rights ruled that Russia had violated the rights of company representatives to a fair trial, but failed to find evidence that Russian authorities had intentionally misused legal proceedings to bankrupt and dismantle the company.
Although that verdict was dismissed on appeal in 2011, each defendant subsequently entered into deferred-prosecution agreements in which they "recognised that aspects of the…transaction were fraudulent".Mr Greenberg has twice tried to have the state's case against him dismissed in "summary judgment" (ie, without a full trial) but failed.
Microbicides based on antiretroviral drugs such as TFV (1% gel) showed moderate efficacy in the CAPRISA 004 clinical trial, but failed to inhibit sexual transmission of HIV-1 in the VOICE Phase IIb clinical trial.
This could be an indication of the patient trying to manipulate his eye movements in the very beginning of the trial, but failed in contrast to the putative manipulations of the relative fixation time.
Thus, we now have an original trial suggesting benefit in both low and high severity risk, with a constant relative risk reduction but variable absolute reduction, and two subsequent trials mimicking the low and high ends of the original trial but failed to repeat the positive findings.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com