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Well-designed HCT trials benefit from standardized criteria for defining diagnoses, treatment plans, and graft source selection.
Conversion to McDonald MS was reported by only two of the trials: BENEFIT (2001 criteria) and REFLEX (2005 criteria).
Correspondingly, these trials benefit most from TMS at the appropriate frequency (see Supplemental Experimental Procedures).
Of these trials, benefit was found in five studies evaluating plasmapheresis or immunoadsorption, and small, nonrandomized controlled studies suggested benefit from rituximab or bortezomib 33, 120, 122, 124– 130, 130– 130.
Indeed, even though it is clear that clinical trials benefit future patients with the disease, there is little evidence to suggest that they benefit those patients that are taking part in them.
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Founded by Fernanda Kellogg and Kirk Henckels, the trials benefited the Millbrook Fire Department Rescue Squad, for which they have raised more than $120,000 over the last 10 years.
Designing and prioritizing successful clinical trials benefits from increased community physician input.
In both studies, trial benefits persisted further than expected beyond the intervention.
Post-trial benefits will not be provided through a state-run health care system after the VHX trial.
For operational research, the obligation to provide post-trial benefits is better articulated as an obligation to change treatment practice.
This trial benefits from rigorous design in terms of independent randomisation, blind rated assessments, and a clearly protocolised complex intervention.
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CEO of Professional Science Editing for Scientists @ prosciediting.com