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The central design of Phase 3 microbicide clinical trials assesses the relative reduction in risk of HIV between participants randomized either to an active or a control/placebo product.
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Clinical trials assessing antidepressant therapies typically include separate assessments of efficacy (benefit) and adverse events (risk).
They are known as Intact trials, not "intact"; the term is an acronym for "Iressa nonsmall-cell lung cancer trials assessing combination therapy".
Yet, in the thrall of wartime transfusion, blood had never been treated like an experimental drug and subjected to rigorous, randomized clinical trials assessing risk and benefit.
Six trials assessed hemodialysis, whereas 1 trial each assessed continuous venovenous hemofiltration and continuous venovenous hemodiafiltration.
Recently, more clinical trials assessing the diagnostic accuracy of presepsin have been published.
Two trials assessed exercise or orthotic intervention groups compared with a control group [55,56].
Overall, 45% (38/84) of clinical trials assessed involved analysis of marketed products after their introduction.
Five of the trials assessed footballers under the age of 19 years.
Of the included trials, only seven trials assessed periodontal outcomes (Tables 2 and 3) [16, 16, 23, 25, 28, 30, 31].
Data from prospective randomized trials assessing restrictive vs. liberal RBC transfusion thresholds have largely favored a restrictive approach [43].
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