The trials assessed the efficacy of memantine across key AD domains (cognition, ADL, global assessment, and behavior) using standard scales.
Moreover, trial follow-up was short (only 10%% of trials assessed primary outcomes beyond 30 days from randomization), precluding mean or long-term assessment of patient-centered outcomes.
Two trials assessed exercise or orthotic intervention groups compared with a control group [55,56].
Overall, 45% (38/84) of clinical trials assessed involved analysis of marketed products after their introduction.
Five of the trials assessed footballers under the age of 19 years.
Six trials assessed hemodialysis, whereas 1 trial each assessed continuous venovenous hemofiltration and continuous venovenous hemodiafiltration.
The procedure adopted will be reviewed, and its suitability for future trials assessed.
Method quality of the trials, assessed using the PEDro scale, had a mean score of five (range three to seven).
Four trials assessed total sway magnitude [16, 27, 33, 52, 57] and sway velocity [38, 40, 52, 57, 62] for the ACL-non-injured leg.
Of the included trials, only seven trials assessed periodontal outcomes (Tables 2 and 3) [16, 16, 23, 25, 28, 30, 31].
As a result, we found that patients' follow-up was short since only 12% of trials assessed primary outcomes beyond 30 days from randomization.
