From an ethical perspective, it is desirable that trials ascertain and report all deaths regardless of whether they appear to be related to study conduct or intervention, are unforeseen or non-specific.
Our results were compared with those from industrial trials, to ascertain if the scratch test could be used as a relatively cheap and effective alternative to expensive engine trials.
The C.D.C. and N.I.H. should conduct clinical trials to ascertain the optimum dosages and dose schedules (how many doses at what intervals) to prevent flu in that age group.
The authors aimed to systematically review these trials to ascertain the role of natriuretic peptide administration in the management of cardiovascular surgery associated renal dysfunction.
The results provided the foundation for phase 2/3 clinical trials to ascertain the clinical efficacy of FLT3 inhibitors and HHT in combination.
In order to obtain a more definitive answer, the Lung Adjuvant Cisplatin Evaluation Biomarker (LACE-Bio) collaborative group undertook a pooled analysis of KRAS mutant vs. wild type patients in four different trials to ascertain if KRAS mutational status had an effect on patients who received adjuvant chemotherapy.
Four of the eleven empirical studies [5], [21], [27], [28] met all four of the criteria for studies investigating study publication bias (inception cohort, complete follow up of all trials, publication ascertained through personal contact with the investigator and definition of positive and negative findings clearly defined).
All five empirical studies [13] [15], [17], [18] met all five criteria for studies investigating ORB (inception cohort, complete follow up of all trials, publication ascertained through personal contact with the investigator, definition of positive and negative findings clearly defined and comparison of protocol to publication).
Of course, larger controlled trials would ascertain our observations.
Most recommend conducting well-designed large-scale trials to ascertain the effectiveness.
