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Compared to decoding analyses, conventional statistical analyses can be difficult to interpret because many factors affect the resulting estimates of significance (e.g., whether or not the assumptions of the response distribution are met, how many subjects and trials are tested, whether there were correlations among the data, etc).
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To deliver a flat RPE monolayer, current phase 1 trials are testing synthetic substrates for RPE transplantation.
Chronic kidney disease is assuming epidemic proportions, and an increasing number of clinical trials are testing treatments developed to improve morbidity and mortality.
Small molecule inhibitors are in various stages of development [177] and clinical trials are testing the efficacy of TGFβ monoclonal antibodies for treatment of diabetic nephropathy and idiopathic pulmonary fibrosis [58].
Other clinical trials are testing drugs that promote the removal of amyloid plaques from the brain.
In the United States, hundreds of clinical trials are testing the safety and efficacy of new biologic therapies for all three breast cancer subtypes.
Ongoing clinical trials are testing HDAC inhibitors for the treatment of GBM (NCT01378481, NCT00302159).
Now, ongoing clinical trials are testing these drugs as treatments for osteoporosis.
Several ongoing trials are testing the efficacy of regorafenib in combination with chemotherapy.
At least two ongoing clinical trials are testing interventions designed to increase adherence among prevalent kidney transplant recipients [ 24, 25].
Current clinical trials are testing CD3 ζ and γ-based CIRs (Lamers et al, 2002) with a trial likely to test CD28- ζ receptors in the near future.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com