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Two recent trials are relevant for deciding between these hypotheses.
We must also be careful that the few per cent of cancer patients who do enter trials are relevant to the many who do not.
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This interpretation is compatible with an earlier H2 [15]O PET study on reversal learning which showed stronger MTL activation when the outcome of trials was relevant for subsequent behavior than when subjects were asked to guess and the outcome of trials was irrelevant for subsequent choices [41].
Two of the full journal reports described multiple trials: for one of these reports only one trial was relevant to mental health, for the other report two trials were relevant.
While federal regulations require a prospect of direct benefit, from an ethical perspective indirect benefits, such as the advantages of being in a clinical trial, are relevant.
The study follows the MRC framework for developing and evaluating complex interventions [ 26]: this descriptive report highlights how preliminary findings inform a definitive trial and how details of the context of a trial are relevant to its evaluation.
Results from the TML trial are relevant, as they suggest that bevacizumab itself has activity post progression and raise the possibility that the events of disease stabilisation observed in our study could be due to effects of bevacizumab alone (Grothey et al, 2008; Bennouna et al, 2013).
Of 51 studies initially retrieved, two articles from one clinical trial were relevant and included.
In cases where PS was unsure as to whether the trial was relevant, a second review author (RJH) was consulted.
30 However, this trial is relevant to US practice but not to European practice and it was limited to patients at high risk of uterine atony, with neither surgery nor anaesthesia standardised and blood loss estimated visually.
The manufacturer argued that the conclusions from the breast cancer trial were relevant to a range of different types of underlying diseases and to the performance of the biosimilar in general.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com