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These trials are mainly intended to establish whether the drug is safe, but the study of more than 13,000 patients in 346 trials found that patients had significantly better outcomes where genetic profiling took place.
These trials are mainly focused on indications beyond CDI, such as inflammatory bowel disease (IBD).
The trials are mainly focused on the therapeutic utility of agonists for TLR3, TLR7, and TLR9.
Ongoing phase II trials are mainly in myeloma (associated with bortezomib or lenalomide), glioblastoma patients (associated with chemoradiation), pancreas (associated with gemcitabine and radiation) and lung.
First of all, it must be noted that literature is mainly made of expert opinions and international surveys; the few reported clinical trials are mainly descriptive (retrospective and prospective); because of technical and ethical problems, Randomized Clinical Trials (RCTs) are totally lacking.
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Because the design of clinical trials is mainly based on demonstrating the efficiency of therapeutic procedures, these studies cannot be widely generalized, especially in complex multifactorial diseases such as vascular disease.
When applied to forests, so far, Nelder trials were mainly used for exploring growing stock and productivity in terms of dendrometrical mean and sum values per hectare.
The variability in the cost-effectiveness ratios among trials is mainly due to variability in the years of life added by the ICD among the trials and, by extension, among patient subgroups.
Although populations in endemic and nonendemic areas are not comparable, we believe the lower mortality in our study than in the quinine groups of these two trials is mainly ascribable to the availability of optimal treatments for organ failures and to the better baseline health status of our population.
The included trials were mainly done in North America and Europe.
Phase II clinical trials were mainly proposed with oral formulations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com