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But clinical trials are difficult to perform with children.
Such trials "are difficult to execute and expensive to complete," said Dr. Kenneth Shine, the former president of the Institute of Medicine and now a fellow at the RAND Corporation, "but they are essential because bad studies only lead to bad information".
Large trials are difficult to initiate and their results difficult to interpret and compare.
Innovative approaches are particularly adapted to the paediatric and neonatal populations, as clinical trials are difficult to conduct, need adapted designs in order to define the optimal dosage regimen in many diseases and therapeutic areas.
Animal models have been difficult to develop and very costly, while clinical trials are difficult to design and perform in ACHD, leaving gaps in our understanding of the pathophysiology and treatment of congenital heart disease.
However, because the population is so fragmented, support for medical research and clinical trials are difficult to come by.
Similar(28)
As cognitive control was required throughout the whole SART, a specific increase of activity in the lateral prefrontal cortex in only some trials is difficult to explain.
This is probably because in this type of drugs, the constancy assumption will often not hold, as the placebo effect in previous placebo-controlled trials is difficult to rule out.
As blinding of participants in dietary trials is difficult to achieve, we scored the trials based on the intensity of the dietary advice given to the randomised groups.
However, the posture content between trials was difficult to compare at face value due to variations in naming of a posture across different styles of yoga.
Consequently the results of this trial are difficult to evaluate.
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