WASHINGTON — The Supreme Court indicated Monday that it might soon have something significant to say about whether and when video coverage of federal trials is appropriate.
Some clinical heterogeneity was therefore inevitable, even when patients in the trials were similar, with similar conditions, when trial designs included both randomisation and double-blinding, and when the duration of trials was appropriate.
There were only three eligible trials, with five comparisons, in a total of 551 patients, where one biologic therapy (axitinib, cediranib and panitumumab) was compared with different biologic (bevacizumab) added to the same standard treatment, so that the trials were appropriate for comparison.
Data sets drawn from studies that involve an intervention trial are appropriate for this RFA; these proposals should address the approach to handling intervention effects when exploring etiologic questions.
Despite these limitations, we believe that the participants of this trial are appropriate subjects to investigate whether exogenous melatonin administered chronotherapeutically can restore patient circadian function, improve sleep quality, health-related quality of life, and survival.
The study design of a randomized controlled trial is appropriate for the underlying research question.
Given these results and the programme's broad dissemination, testing the programme in a randomised control trial is appropriate.
For the most accurate measurement of overall antibiotic effect on resistance in communities, a cluster-randomized intervention trial is appropriate (45 ).
The initial telephone screening procedure implemented in this trial was appropriate, and only one patient required attendance for further screening before a descision could be made; furthermore only one patient refused consent to participate in the trial.
