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Only 3 (6%) of the reviewed prophylactic trials applied stratification for migraine attack frequency.
Thirty-one percent of acute RDB trials applied the recommended "pain free at 2 h" as the primary efficacy measure while 49% of acute RDB trials applied this measure as a secondary endpoint.
Few recent therapeutic trials applied rTMS and tDCS in migraine prevention, and their results were conflicting [29 31].
As mentioned above, anti-inflammatory clinical trials applied at the initial phase of sepsis failed to tackle the devastating effects of sepsis and to translate into improved survival.
This review presents general aspects concerning clinical trials and cutaneous mycoses, and ends with a discussion of the design of clinical trials applied to these infections, with the aim of facilitating critical interpretation of studies published in the literature.
Other standard exclusion criteria for MPH drug trials applied [ 12].
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Furthermore, three Italian groups conducted open trials applying silymarin combined with other agents (see Additional file 3).
Comparison data from trials applying harmonized trial design will lead to optimized immunotherapeutic treatment protocols to maximize clinical efficacy while minimizing toxicity.
Some of the acute trials apply even more rigorous primary efficacy endpoints, such as "pain free at 30 min" [82] or "total symptom relief at 1 h" [59].
The results of some laboratory studies and worldwide field trials applying ex situ and in situ MEOR technologies were compiled and interpreted.
The evidence for optimal insulin treatment in type 1 diabetes is mainly based on randomised controlled trials applying a parallel-group design.
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