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Electronic PRO data capture (ePRO) in daily oncological practice or clinical trials allows to measure subjective physical health status and psychosocial burden.
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The randomized controlled trials allowed to objectify the efficacy of the psychotherapies in multiple pathological contexts, as we will see with the example of bipolar disorders.
Such original trials allowed to receive the opinion of 25 participants (from 158 invitations), from which only seven of them declared "High" or "Very High" experience on applying agile technologies in software projects.
The IT components of modern healthcare organizations and benchmarking projects may foster the development of "platform" trials, allowing to focus on diseases or syndromes, comparing multiple interventions within different domains of treatment [10].
Adaptive trials allow to change aspects of the study while this is ongoing, depending on analyses of data obtained from patients enrolled in the same or other studies [ 10 ].
The ESCAPE trial allows to examine these potential benefits in a setting of a well designed, sufficiently powered randomized trial.
APRV settings and the protocol for sedation used in this trial allowed to reach sufficient spontaneous breathing for the majority of the patients without any major complication and with a tidal volume below 8 ml/kg PBW.
Although this interesting behavior was only present in one dataset, the ability to analyze individual trials allows us to identify neural correlates.
Adding optogenetic stimulation on certain trials allows mice to overcome this inherent bias.
Cluster trials allow resources to be used to best advantage and due to this they are likely to be less expensive than the "traditional" randomized controlled trial.
Analysis of the efficacy trials allows some conclusions to be made about the efficacy of individual drugs and dosing regimens in preventing episodes of clinical malaria.
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