There are ongoing randomized, controlled trials aiming to demonstrate a mortality benefit.
Most clinical trials aiming to reduce the burden of sedation only enrolled patients after 48 hours of mechanical ventilation [7, 18, 28].
Abnormal oxidative stress is an established feature of Alzheimer's disease, but clinical trials aiming to reduce oxidative stress have not yet proven an effective therapy for dementia patients.
Therefore, further randomized controlled trials aiming at evaluating the impact of continuous control of P cuff on VAP incidence are required to evaluate the efficiency of this preventive measure.
Methods: Review of controlled, randomized clinical trials aiming to investigate postoperative complications in which continuous postoperative epidural local anesthetic was administered in patients scheduled for colorectal surgery with an anastomosis.
It is only recently that experts have proposed that in observational studies and clinical trials aiming to investigate strategies to prevent DCI, the 2 main outcome measures should be: (1) cerebral infarction identified on CT scan or magnetic resonance imaging or proven at autopsy, after exclusion of procedure-related infarctions; and (2) functional outcome [1].
Applying this definition to radiopharmaceuticals underlines the clear distinction between the industrial manufacturing in a framework of "licensing" i.e. marketing authorisation or clinical trials aiming at a marketing authorisation versus the local, extemporaneous preparation of radiopharmaceuticals being it for patient diagnosis or within the framework of a local clinical trial.
It is known that several HDAC inhibitors are now in clinical trials aiming at AD therapy, but delivery of the drug to the brain remains a major obstacle [30].
However, in sensitivity analyses there was no qualitative difference in any of the outcomes analyzed when trials aiming at reaching recommended full dose ARB therapy were compared to trials where ≥80% of patients in the combination group reached the target dose of the recommended ARB.
10 16 Trials aiming at pre-eclampsia prevention have yielded mixed results.
Further randomized clinical trials aiming to identify the optimal STEMI management strategy for octogenarians are warranted.
