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A pooled analysis of five poorly recruited randomized trials addressed this issue and estimated a 59% CR-rate for thermoradiotherapy compared with 41% for irradiation alone.
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Results from two important trials addressing this issue are imminent.
Future randomized clinical trials addressing this issue would be of tremendous benefit and are greatly anticipated.
In 2006, Nelson [ 27] considered seven randomized trials addressing this issue with locoregional treatment.
It is noteworthy that the ongoing clinical trials addressing this issue (PIVOT and ProtecT) are not adequately powered to detect a survival benefit of this magnitude.
Trials addressing this issue were rare; only the BLESS study reported that there was no evidence of macrolides causing QTc prolongation or arrhythmia.
Recently several trials addressing this issue have been finalised, and they provide a convincing answer: the newer drugs are no better than the older ones.
However, a lack of randomized-controlled trials addressing this issue means there is insufficient evidence to definitely determine whether a universal approach to screening should be the gold standard of care.
Sixth, since the dose response effects of exercise on measures of adiposity in overweight and obese children and adolescents remain elusive, it is suggested that future randomized controlled trials address this issue.
Fifth, since the dose response effects of exercise on depressive symptoms in adults with AORC are not known, it is suggested that future randomized controlled trials address this issue.
Between July 1997 and December 1999, we performed the first prospective randomized clinical trial addressing this issue in 159 HSCT recipients who received a prophylactic platelet transfusion when the morning platelet count fell below a 10,000/microL (10K) or 20,000/microL (20K) threshold.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com