Your English writing platform
Discover LudwigSuggestions(2)
Exact(4)
Three methods for intervening in the amyloid cascade have thus far been tested in clinical trials: active immunization, passive immunization, and modulation of γ-secretase [ 4, 5].
51, 52 In both trials, active treatment group consisted of the dihydropyridine CCB nitrendipine with possible addition of ACE inhibitor and/or thiazide diuretic to achieve SBP <150 mmHg and reduction of ≥20 mmHg from baseline.
For randomized clinical trials, active interventions such as aerobic exercise, isometric exercise, health education programs with monitored exercise sessions, or physical therapy-driven exercise treatments were compared with control groups that received no intervention (Table 2).
'Alzheimer disease' and 'mild cognitive impairment' were used as the search terms in the condition field, and the following search terms were used for the outcomes: 'MRI'PETPET'magnetictic resonance imaging'positronron emission tomography'hippocampalpal volume'brainain volume' and 'brain atrophy' – only trials active within the last 10 years were considered.
Similar(55)
Mice were subjected to once daily 100-trial active avoidance sessions during 5 consecutive days.
In the Syst-Eur trial, active treatment reduced mean BP from 174/8 6mmHg to 151/79 mmHg and significantly reduced the rate of stroke and cardiac endpoints.
In the Syst-China trial, active treatment had a slightly less potent effect on BP reduction compared to that in the latter trial and active treatment was associated with a 38% reduction in stroke, 37% reduction in CV endpoints, and 39% reduction in all-cause mortality, all of which were statistically significant.
Conduct of trial – Active bleeding episode (haematemesis, haematochezia, melena) from a potential variceal source should be confimed by a medical team (the ER physician, the ICU physician, the investigator).
In the Action in Diabetes and Vascular Disease: Preterax and Diamicron-MR Controlled Evaluation (ADVANCE) trial, active BP treatment reduced the risk for renal events by 21% with SBP as low as 110 mmHg regardless of the baseline BP (13).
According to duplicate publications of the same trial and active control noninferiority trials we show in Table 1 the preliminary results with 12 studies [17 28].
In trials comparing active and inactive treatments (e.g., placebo, no intervention), we can reasonably expect the active treatment to be always favored by small-study bias.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com