Exact(3)
In the aborted IS trials, a decrease in brain tissue oxygen tension and a tendency to brain metabolic distress were observed.
For both trials, a decrease in haemoglobin of ≥2 g/dL was used to define the clinically meaningful end point as previously described by us and others.
In a post hoc analysis of four prospective randomized intravascular ultrasound trials, a decrease in LDL cholesterol levels and an increase in HDL cholesterol levels were independent predictors of atheroma regression (20).
Similar(57)
In addition, it has been shown conclusively that, during a decremental PEEP trial, a decrease in compliance from a maximum value indicates lung collapse [ 5].
Based on blinded data, mean PRO measures improved during the course of the trial (a decrease in DLQI scores indicates an improvement; an increase in the SF-36 and EQ-5D indicates improvement).
In one randomized controlled trial a decrease in the incidence of VAP was noted in patients receiving probiotics despite the fact that their colonization rates were left unaffected [ 39].
Previous studies of vitamin D supplementation have produced inconsistent results, with some trials showing a decrease in inflammatory markers and others showing no effect.
In contrast, the same dosage of MK-801 in small-reward trials produced a decrease in RT as compared to the control condition, implying an improvement of performance.
Within-group comparisons in three trials showed a decrease in LPP intensity and associated variables in both experimental and control groups at different follow-up intervals compared to baseline [ 46– 48, 51].
Finally, three trials reported a decrease in medication use, which is an important, relatively new finding, because health care utilization outcomes were not assessed in any of 21 diabetes self-management trials included in a previous review (23).
The GRADE system incorporates a subjective assessment of consistency as criteria for grading the quality of evidence and, in the setting of unexplained heterogeneity across trials, suggests a decrease in grade [ 11].
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