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Due to extremely different choices trialists made on outcome reporting methods, we had to abandon attempts at meta-analysis.
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However, it is imperative that clinicians and clinical trialists make every effort to effectively communicate with all patients and actively promote their understanding of the potential risk of treatments or trial participation.
Can Schleck, who is not a strong time trialist, make his lead stand up?
We did not consider treatment by centre interaction this study, partly because clinicians and trialists have been making efforts to standardize the conduct and management of multicentre trials via, for instance, uniform patient selection criteria, staff training, and trial monitoring and auditing to reduce heterogeneity of treatment effects among centres.
"This is Premier League, so I think it's even better," said the former Leeds trialist who made his Jags debut in Saturday's 0-0 drawithth St Johnstone.
To propose a tool to assist trialists in making design decisions that are consistent with their trial's stated purpose.
Clinical trialists must make the additional effort to estimate the minimum clinically important treatment effect that is relevant to practicing clinicians.
Publication would allow trialists to make more informative decisions as to which strategies to use, and would add to the current limited evidence base.
Treweek and Zwarenstein have argued that "if we want evidence from trials to be used in clinical practice and policy, trialists should make every effort to make their trials widely applicable, which means trials should be pragmatic in attitude" [ 11].
Reviewers should scrutinise trials with missing outcome data and ensure that an attempt to contact trialists is always made if the study does not report results.
We have strongly encouraged the trialist to make these unreported results publicly available.
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