The randomization list was generated and centrally applied with concealment by the Coordination Centre for Clinical Trials with the use of randomly selected block sizes of 4, 6 and 8 patients stratified according to centre.
The most positive outcome in this study was patients' positive attitude towards clinical trials with the use of antidepressant.
This study has demonstrated the potential improvement of the study design step of clinical trials with the use of a patient count cohort system.
Therefore, more clinical trials with the use of appropriate molecular tools are necessary to determine which main outcomes and additional immune- and inflammation-associated variables are clearly influenced, and particularly the cause of these changes in the development of IBD.
Information on the effect of B vitamins on global cognitive function from the 4 trials with the use of change in the domain-composite score and the 7 trials that used end-treatment MMSE-type scores is shown in Figure 3.
Complexity of the decision was categorized into subgroups by consensus between three researchers (LG, IH, PT): low (open trial or randomized trial without blinding), or high (randomized trial with either the use of placebo, or blinding, or both).
This is an adaptive dose-finding trial that combines a new trial design with the use of immunological biomarkers to develop a new treatment for type 1 diabetes.
This study, reporting on the first experience with a new technique at a single institution, is a controlled trial, but with the use of historical controls.
On the third and fourth visits, the subjects completed two experimental trials, either with the use of a CG CGG trial) or without the use of a CG CONN trial) during post-exercise period after performing two repeated bouts of exercise, separated with 4 h of rest (Ex1: 9:00–10:00, Ex2: 14:00–15:00).
