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The same methods were used for the Pseudotsuga menziesii trial, with the exception of treatments 10 and 11 which were applied in late July 2012.
Interestingly, similar analysis of the fluorescence treatment group (experimental vs. control) yielded ratios of 1.05, 1.16, 1.21, 1.16, 1.14 and 1.26, indicating that the difference between the averages is smaller for the fluorescence trial (with the exception of the retrograde contraction rate) than for the independent control cohorts.
Additional chemo-, immuno-, radio- or hormone therapy was not permitted during the trial (with the exception of hormone replacement therapy).
Selected blood parameters remained within the reference range before and after the feeding trial, with the exception of total serum proteins that were below the lower value of reference range at both times.
RB is responsible for the sample size calculation, has contributed to the case record forms and is responsible for the implementation of the trial data management using the ProMISe software; he is also the biostatistician for this trial, with the exception of the cost-effectiveness analysis.
At week 20, all goats were positive to PPD-B (bovine reactors), and these results were maintained during the rest of the trial with the exception of one goat that tested bovine-negative at week 24 and another that was an avian reactor at week 28 (see Table 2).
Similar(54)
Soluble solid contents were almost comparable among the different trials, with the exception of AS that was significantly higher.
The remaining six studies were open label trials, with the exception of Dehasse [1] and therefore were classed as providing level 4 evidence (equivalent to case series and poor quality cohort and case control studies, and so with a higher risk of bias).
All of the trials, with the exception of two, were small [ 31, 32].
All other toxicities were in the range of other trials with the exception of grade 3 or 4 lymphocytopaenia.
All of the 14 included studies were randomised controlled trials, with the exception of one [ 73] that was non-randomised.
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