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Multicentre, randomised controlled trial with pragmatic design.
Additionally, when the correlation between observations from the same patient is accounted for in the analysis, this design will typically have higher power than a parallel group trial with an equivalent number of observations.
Provided the analysis accounts for correlation between observations from the same patient, this design will typically have higher power than a parallel group trial with an equivalent number of observations.
It was a no-placebo trial with an ABABA design.
The choice was made after comparative trials with an equivalent North Eastern Railway Pacific, classified 'A2'A2
Only trials with a comparative design were included.
Trials with 'open' designs also appear to benefit recruitment.
BoTN is a prospective, randomized, double-blind, placebo-controlled trial with a randomized withdrawal design.
Prospective multicentric academic trial with a non-randomised design.
This quasi-experimental trial with a non-equivalent control group uses a before-after design [ 21].
A parallel group design with equivalent baseline values as a result of randomisation is proposed.
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