Sentence examples for trial were to define from inspiring English sources

The primary objectives of this trial were to define the maximum tolerated dose (MTD), and to identify the optimal biologically active dose of MDX-H210.

The objective of this phase I trial was to define the recommended doses of oxaliplatin when used in this setting.

One of the difficulties in designing the trial was to define clearly the radiological criteria for 'advanced disease'.

The main purpose of the proposed pilot trial is to define the distribution in outcome measures, as well as the feasibility of recruiting and retaining patients for a more definitive trial.

The primary end point of this trial was to define a chemotherapy regimen with an acceptable toxicity profile that could potentially improve the therapeutic efficacy of gemcitabine in patients with pancreatic cancer.

The primary objective of both trials was to define the pharmacokinetic properties of granisetron after a single SC dose of APF530 in cancer patients receiving chemotherapy.

A key recent additional component of Phase II trials is to define the presence of the drug target in the tumour and to relate target levels to clinical activity.

The second major goal of our trials was to define the toxicity of this triplet chemotherapy in the two patient populations: Overall, the toxicity of the GemFOx combination chemotherapy in both patient populations was manageable.

Another issue of discussion in the DOMUS trial has been to define the inclusion criteria.

The primary objectives of phase I trials (PIT) are to define the toxicity profile of a new drug and to determine the dose for further evaluation in phase II trials.

An alternative, complementary approach that may be particularly useful in the early short-term trials would be to define mechanism-based pharmacodynamic biomarkers that reflect agent activity and correlate with efficacy in preclinical models, and determine their utility in humans.