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Another randomized, double blind, multicentre, and placebo controlled clinical trial was done by Semiglasov et al. in 2004 [ 94].
A feeding trial was done by Marin, et al (2002) to determine the effect of aflatoxin-contaminated diets on growth and hematological and immunological parameters.
12 The largest and best designed placebo-controlled, randomized clinical trial was done by Govaert et al in The Netherlands during the 1991 1992 influenza season.
Financial competing interests Funding of this trial was done by Austrian Nationalbank Anniversary Foundation, Bjoern Steiger Foundation Germany, Lions Club Vienna, Medical Scientific Foundation by the Mayor of Vienna, Ministry of Science and Traffic, Austria for EC program, Philips Medical Systems and The Laerdal Foundation for Acute Medicine.
The first multi-center trial was done by Tani and colleagues in 1998 [ 35], where 37 of 70 subjects with severe sepsis were treated with PMX-DHP and the treatment group demonstrated an 18% reduction in absolute 14-day mortality compared to the control population.
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The random allocation into either the intervention or control group by order of recruitment into the trial is done by Dr Tseng, who then provides this information to Associate Professor Jordan in sealed opaque envelopes.
The assessment of statistical heterogeneity among trials was done by visual inspection i.e. the overlap of the confidence intervals among the studies, and by the Chi square (P-value) of heterogeneity in the meta-analyses.
Assessment of statistical heterogeneity among the pooled trials was done by visual inspection of forest plots, by the Chi square (p-value) and by calculating the I statistic (calculated as I =100% x (Q-df )/Q; where Q is Cochrane's heterogeneity statistic and df is the degrees of freedom).
Assessment of statistical heterogeneity among the trials was done by visual inspection of forest plots, by performing the Chi (assessing the P-value) and by calculating the I statistic (calculated as I =100% x (Q-df )/Q; where Q is Cochrane's heterogeneity statistic and df is the degree of freedom).
Almost all planning, design, building, blazing, marking and maintenance of the trials is done by by volunteers and coordinated by the Trail Conference.
Prosecutors accused Mathew Martoma, a former SAC employee, of obtaining secret data about clinical trials being done by the drug companies Elan and Wyeth, and using the information both to earn trading profits and avoid losses, a total of $276 million.
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