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Most patients reported headache improvement a few days after the HF10 SCS trial was commenced (patients 1, 3 and 4), whereas in patient 2 different stimulation programmes were tried before achieving the maximum benefit.
The trial was commenced in August 2008.
A trial was commenced with appearance of a green box representing the starting position (Center On).
A second, larger-scale, double-blind, randomized clinical trial was commenced.
If the participant moved his/her arms or feet from the starting position and/or lost balance, a new trial was commenced.
Although gemcitabine is now approved and licensed in Australia for numerous malignancies, at the time this trial was commenced in 2001, it was only routinely available in Australia in the settings of lung cancer and pancreatic cancer.
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Many important methodological issues in animal studies are not adequately addressed before clinical trials are commenced (Box 1).
A left buttock recurrence occurred in January 2008 and vaccinia melanoma cell lysate (VMCL) vaccine trial therapy was commenced.
In March 2008, multiple nonresectable nodules developed over the thigh and leg, and VMCL vaccine trial therapy was commenced, which continued for 8 months.
Trial medication was commenced a minimum of 5 days prior to the planned date of surgery and continued for up to 31 days.
In December 2008, regrowth occurred, and a Rose Bengal (PV-10; Provectus Pharmaceuticals, Inc., Knoxville, TN, USA) trial therapy was commenced for 5 months with some initial effect, but deposits eventually grew and further nodules appeared.
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