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In recent years, a number of researchers have been working on developing adequate methodologies to conduct cluster-randomised trials, reinforcing trust in how such trials can produce reliable evidence in situations when group randomization is to be preferred to individual one [ 14, 30, 31, 33, 34, 37, 57].
We have recently launched the TRUST trial (The Randomized Uterine Septum Transsection trial: NTR1676) that randomizes women with recurrent miscarriage between hysteroscopic metroplasty and expectant management.
The Trust trial was a multicentre, open-label, uncontrolled clinical trial carried out in 30 centres in Australia, Europe Denmark, France, Germany, Hungary, Italy, The Netherlands, Norwayy and Sweden and South America Argentina, Brazil and Chilele) between September 2006 and May 2009.
By contrast, 93% of the daily HM transmissions in the TRUST trial were successfully received.
The primary objective of the Trust trial was to assess the immunogenicity of repeated exposure to 150 μg corifollitropin alfa in a standard GnRH antagonist protocol in normal responder patients weighing >60 kg with a normal BMI (18 29 kg/m) and a regular menstrual cycle undergoing up to three cycles of controlled ovarian stimulation (COS) with corifollitropin alfa for IVF and/or ICSI.
The volunteers based their decision to take part in the trials on their trust that the study information provided by the research team and the trial procedures they would undergo would not cause them harm.
ANNALS OF COMMUNICATIONS about Judge Thomas Penfield Jackson, Judge Richard A. Posner, and the Microsoft anti-trust trial in Washington's U.S. District Court... Describes… ANNALS OF COMMUNICATIONS about Bill Gates and the Microsoft anti-trust trial brought by the federal government... Ten-part story describes the trialbefore Judge Thomas Penfield Jackson….
He was widely respected and admired for his professionalism, character and unparalleled skills as a trial lawyer and trusted counselor by his colleagues, clients and friends.
Because pregnant women are rarely recruited for clinical trials, research on drug effects during pregnancy is limited; there is no data from the kind of randomized controlled trials that scientists trust most.
During the 1998 Microsoft anti-trust trial, the prosecution pored over masses of e-mail, looking for a smoking gun.
"We're not doing everything," protests Xiong, a former Microsoft employee during the anti-trust trial years, who is visibly uncomfortable with the Microsoft analogy.
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