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A trial to quantify the impact of handwashing during the perinatal period on neonatal morbidity and mortality is currently underway (http://clinicaltrials.gov/ct2/show/NCT01309321?id=10036&rank=2) which should strengthen the evidence base for this third assertion.
In summary, the PINE study is the first randomised trial to quantify the effectiveness and cost-effectiveness of an epidural injection of local anaesthetics and steroids on the prevention of postherpetic neuralgia in elderly patients with acute-phase herpes zoster.
The CRASH-2 Intracranial Bleeding Study was a prospective randomised controlled trial nested within the CRASH-2 trial to quantify the effect of an early short course of tranexamic acid on intracranial haemorrhage in patients with traumatic brain injury.
Moreover, because advanced-stage pancreatic cancer is frequently accompanied by debilitating symptoms (Schnall and Macdonald, 1996), we designed a phase II trial to quantify the effect of GEM-EPI administration on clinical benefit response as well as objective responses and median survival in patients with advanced pancreatic cancer.
4 6 We designed the Randomised Evaluation of Secondary Prevention by Outpatient Nurse SpEcialists (RESPONSE) trial to quantify the impact of a practical, hospital-based nurse-coordinated prevention programme integrated into the routine clinical care of patients who have sustained an acute coronary syndrome (ACS).
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We first use no-choice mating trials to quantify the prezygotic barriers to hybridization.
We then analysed the data from thirteen randomised clinical trials to quantify the relationship between the dose of R-TFA and the change in the ratios of TC:HDL-C and LDL-C HDL-C in heaLDL-C HDL-C.
We conducted a randomised controlled trial to quantify and draw inferences on the clinical effectiveness of platelet-rich therapy in the management of patients with a typical osteoporotic fracture of the hip.
This was the first trial to quantify and describe benefits of a standalone WBV intervention on exercise tolerance and functional performance of the lower limbs of people with COPD in a community-setting.
To describe the total cardiovascular burden (cardiovascular morbidity or mortality, revascularization or non-traumatic amputation) in individuals with screen-detected diabetes in the ADDITION-Europe trial and to quantify the impact of the intervention on multiple cardiovascular events over 5 years.
POETIC is a two-arm, individual patient randomised controlled trial aiming to quantify the effects and costs of an optimised POCT guided diagnostic and treatment strategy for symptoms of uncomplicated UTI on the overall appropriateness of antibiotic prescribing when compared to a "practice based on best available local guidelines" strategy.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com