The ATAC trial was the first trial to present data comparing adjuvant tamoxifen with an AI, and its results heralded a major change in the endocrine therapy of post-menopausal women.
RAPID-axSpA is the first trial to present data on the efficacy of an anti-TNF agent across the broad spectrum of patients with active axial SpA as defined by the Assessment of SpondyloArthritis international Society (ASAS) criteria (2), including both patients with AS and those with nonradiographic axial SpA.
Mr. Teufel spent five years in prison awaiting trial, only to present a watertight alibi in court: when the kidnapping took place he was working under a false name in an Essen factory that made toilet seats.
Furthermore, the trials had to present a treatment manual and had to document adherence to the treatment manual for the interventions to be classified as 'adequately defined'.
Achieving an accurate early assessment of risk surrounding DILI in clinical trials continues to present a series of critical challenges for the developers of new drugs and biological agents, as well as government regulators.
The issues, Mr. Dunham said, "involve the right to a fair trial, the right to present a defense, the right to call witnesses in your own behalf, the right to force the government to produce evidence it has that is favorable to the defense -- all of those things are on the table".
Tony Fratto, the deputy White House press secretary, said the administration was pleased that Mr. Hamdan received a fair trial, with an opportunity to present a defense against serious charges.
Indeed, that kind of visible industry support -- sending witnesses to testify in a high-profile, high-pressure trial -- was needed to present a convincing case in court.
Major Hasan, 42, has been representing himself for months, and has made few attempts since the trial started Aug. 6 to present a defense.
To clarify and illustrate sample size calculations for the cross-sectional stepped wedge cluster randomized trial (SW-CRT) and to present a simple approach for comparing the efficiencies of competing designs within a unified framework.
