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For any trial to implement a stopping rule successfully there must also be prompt feedback and processing of response and survival data ready for up-to-date analysis.
Since July 2012, an intervention trial to implement a simplified neonatal resuscitation protocol provided by Helping Babies Breathe (HBB) has been ongoing at Paropakar Maternity and Women's Hospital in Kathmandu, Nepal [ 24], which is a central referral hospital of the country and also a teaching hospital for medical and nursing students on all levels.
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The IPaC study is the first randomized controlled single centre phase III trial to implement an early palliative care approach in standard oncological care in the hospital setting in Belgium for patients with advanced cancer.
The Look AHEAD Trial is one of the longest prospective randomized clinical trials to implement a lifestyle intervention targeting weight loss and improvement in fitness in overweight and obese adults with T2DM.
One GP participated in a trial to implement the screening protocol for cardio-metabolic prevention, targeting all patients >55 years old [ 16, 24].
Anti-Id mAbs mimicking the human high molecular weight melanoma-associated antigen have been tested in a clinical trial to implement active specific immunotherapy (Mittelman et al, 1990).
Phase 2 involves a randomised controlled trial to implement and evaluate the programme.
We performed a rigorously designed cluster-randomized trial to implement IC interventions in small rural hospitals in the western United States.
The overall approach of the SHINE Trial is to implement a health system-based project in which randomized behavior change interventions are delivered by VHWs.
In this trial we want to implement a cognitive based education programme, which is theoretically based on current understanding and knowledge of pain mechanisms.
The aim of this randomised controlled trial (RCT) is to implement a six month, individualised exercise and nutrition program commencing within 14 days of surgery for PFF, that will result in clinically and statistically significant improvements in terms of physical function, body composition and QOL at an acceptable level of cost and resource use and without increasing the burden of caregivers.
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