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Unfortunately, there is still no randomized, prospective, and controlled trial to document the aforementioned intriguing findings.
The global health community has conducted no trial to document that BCG, DTP, OPV and MV have the intended effects on child survival and only those effects.
In addition, interviews will be conducted at the end of the trial to document the experience of service users in receiving SMCM.
A research nurse interviewed patients every 6 months during the trial to document utilization of weight loss assistance therapies and medication by type, dosage, and frequency.
Tick charts will be completed by health professionals caring for all women and infants in the trial, to document the key resource and staff inputs not recorded by the trial data collection forms.
It is also essential to exclude differential diagnoses, as well as carrying out an elimination diet trial to document whether food allergens are involved in the development of the disease [ 12, 13].
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As such, it is necessary for trials to document and report fidelity assessments over time and across space, and to use them for program monitoring and improvement.
When selecting a PRO measure for use in clinical trials to document treatment benefit, it is necessary to demonstrate that the selected measure is fit for its intended use in a specific context of use [ 24].
It is unfortunate that this catheter became available in the market long before prospective clinical trials to document its efficacy were carried out, leading to decades of debate about its clinical utility.
Thus, it is not absolutely certain that low- to intermediate-risk patients will benefit from OAC and we should be cautious about recommending OAC for a large number of lower risk patients by using CHA2DS2-VASC scores without data from randomized trials to document its benefit.
In our cohort therapeutic LPs were considered based on baseline CSF opening pressure and symptoms of raised ICP, whereas other studies have used a systematic approach when conducting scheduled therapeutic LPs for phase II trials to document the early fungicidal activity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com